Issue 65, 2016

Gadolinium(iii) based nanoparticles for T1-weighted magnetic resonance imaging probes

Abstract

The development of magnetic resonance imaging (MRI) contrast agents with delicate sensitivity and advanced functionalities has recently received extensive interest. Nanoparticle MRI contrast agents have been synthesized for various potential applications because of their unique properties, such as large surface area, surface modifications for multifunction, contrast enhancement, and conjugation with biomolecules for therapeutic and diagnostic applications. This review summarized the recent progress on Gd-based nanoparticles as T1-weighted MRI contrast agents including inorganic crystalline Gd(III) nanoparticles and Gd(III) chelate-grafted macromolecular nanoparticles. The recent development of Gd(III)-based nanoparticle as multimodal contrast agents including T1-weighted MRI/computed X-ray (CT) and T1-weighted MRI/optical were also included.

Graphical abstract: Gadolinium(iii) based nanoparticles for T1-weighted magnetic resonance imaging probes

Article information

Article type
Review Article
Submitted
25 3 2016
Accepted
19 6 2016
First published
20 6 2016

RSC Adv., 2016,6, 60945-60966

Gadolinium(III) based nanoparticles for T1-weighted magnetic resonance imaging probes

C. Yang, P. Padmanabhan and B. Z. Gulyás, RSC Adv., 2016, 6, 60945 DOI: 10.1039/C6RA07782J

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