Issue 10, 2016

An organic indicator functionalized graphene oxide nanocomposite-based colorimetric assay for the detection of sarcosine

Abstract

Rapid detection of sarcosine is a key requirement for both diagnosis and treatment of disease. We report here a simple yet sensitive colorimetric nanocomposite platform for rapid detection of sarcosine in alkaline media. The approach exploited the benefits of a rapid color-producing reaction between an organic indicator, 1,2-naphthoquinone-4-sulphonic acid sodium salt (NQS), and the analyte of sarcosine species as well as the good catalytic ability of graphene oxide (GO) to the formation of highly colored products due to its good water dispersibility, extremely large surface area and facile surface modification. As a result, a NQS functionalized GO nanocomposite through π–π stacking has been demonstrated to be useful as a highly efficient catalyst system for the selective and sensitive colorimetric determination of sarcosine by providing a nanocomposite-amplified colorimetric response. Meanwhile, the strategy offered excellent selectivity toward sarcosine species against other amino acids as well as a satisfying detection limit of 0.73 μM. More importantly, by using an electrochemical method, a credible sensing mechanism of GO nanocomposite-based colorimetric platform for a special analyte determination can be easily verified and elucidated, which also provides an attractive alternative to conventional characterization strategies.

Graphical abstract: An organic indicator functionalized graphene oxide nanocomposite-based colorimetric assay for the detection of sarcosine

Supplementary files

Article information

Article type
Paper
Submitted
11 1 2016
Accepted
12 2 2016
First published
16 2 2016

Nanoscale, 2016,8, 5488-5496

An organic indicator functionalized graphene oxide nanocomposite-based colorimetric assay for the detection of sarcosine

Z. Xue, B. Yin, H. Wang, M. Li, H. Rao, X. Liu, X. Zhou and X. Lu, Nanoscale, 2016, 8, 5488 DOI: 10.1039/C6NR00005C

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