Issue 32, 2013

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

Abstract

The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.

Graphical abstract: Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

Supplementary files

Article information

Article type
Communication
Submitted
16 1 2013
Accepted
06 3 2013
First published
06 3 2013

Chem. Commun., 2013,49, 3339-3341

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

J. R. Brender, J. Krishnamoorthy, G. M. L. Messina, A. Deb, S. Vivekanandan, C. La Rosa, J. E. Penner-Hahn and A. Ramamoorthy, Chem. Commun., 2013, 49, 3339 DOI: 10.1039/C3CC40383A

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