Issue 29, 2024

Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery

Abstract

The properties of nanomaterials make them promising and advantageous for use in drug delivery systems, but challenges arise from the immune system's recognition of exogenous nanoparticles, leading to their clearance and reduced targeting efficiency. Drawing inspiration from nature, this paper explores biomimetic strategies to transform recognizable nanomaterials into a “camouflaged state.” The focal point of this paper is the exploration of bionic nanoparticles, with a focus on cell membrane-coated nanoparticles. These biomimetic structures, particularly those mimicking red blood cells (RBCs), white blood cells (WBCs), platelets, and cancer cells, demonstrate enhanced drug delivery efficiency and prolonged circulation. This article underscores the versatility of these biomimetic structures across diverse diseases and explores the use of hybrid cell membrane-coated nanoparticles as a contemporary trend. This review also investigated exosomes and protein bionic nanoparticles, emphasizing their potential for specific targeting, immune evasion, and improved therapeutic outcomes. We expect that this continued development based on biomimetic nanomaterials will contribute to the efficiency and safety of disease treatment.

Graphical abstract: Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery

Article information

Article type
Review Article
Submitted
18 3 2024
Accepted
09 6 2024
First published
26 6 2024

J. Mater. Chem. B, 2024,12, 7001-7019

Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery

W. Kang, Z. Xu, H. Lu, S. Liu, J. Li, C. Ding and Y. Lu, J. Mater. Chem. B, 2024, 12, 7001 DOI: 10.1039/D4TB00565A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements