Issue 1, 2024

Dual photoresponsive & water-triggered nitric oxide releasing materials based on rhodium-based metal–organic polyhedra

Abstract

The exogenous administration of nitric oxide (NO) is considered a potential therapeutic treatment against a great variety of diseases due to its significant role in multiple physiological functions. Due to the gaseous nature, short lifetime and dose- and tissue-dependent activity of this molecule, the development of new administration procedures is required to control the NO delivery in terms of dosage, timing, and location. In this work, we propose a new molecular material based on robust metal–organic polyhedra (MOPs) for controlled NO release. We select dirhodium paddlewheel complex-based cuboctahedral MOPs (RhMOP), in which NO can chemically coordinate to the open-metal sites at the axial sites of dirhodium paddlewheel moieties. We further prepare amorphous coordination polymer particles (CPPs) by connecting RhMOP with bis(imidazole) linkers at the external axial sites. Both molecular MOPs and polymeric CPPs show relevant NO payloads and the release of NO can be triggered by two different stimuli: light and humidity. We show that imidazole ligands coordinating to the external axial sites of the paddlewheel moieties tune the light-triggered NO release property. We further demonstrate that the size and the extrinsic pores of CPPs are important for enhanced NO release.

Graphical abstract: Dual photoresponsive & water-triggered nitric oxide releasing materials based on rhodium-based metal–organic polyhedra

Supplementary files

Article information

Article type
Paper
Submitted
16 9 2023
Accepted
27 11 2023
First published
28 11 2023

J. Mater. Chem. B, 2024,12, 233-239

Dual photoresponsive & water-triggered nitric oxide releasing materials based on rhodium-based metal–organic polyhedra

F. J. Carmona, T. Negrão Chuba, E. Sánchez-González, J. Pirillo, Y. Hijikata and S. Furukawa, J. Mater. Chem. B, 2024, 12, 233 DOI: 10.1039/D3TB02162A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements