Issue 14, 2024

GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy

Abstract

Photothermal therapy (PTT) is emerging as a promising therapeutic approach for tumor treatment. However, the low therapeutic effect of photothermal agents due to their non-specificity and the monotherapy approach remains challenging for further applications. Herein, tumor microenvironment (TME) specifically responsive POM@MOF composites with sequential activation properties were constructed by encapsulating POMs (PMo12, short for H3PMo12O40) into metal organic framework (MIL-101) carriers for synergistic PTT/chemodynamic therapy (CDT) treatment. PMo12@MIL-101 releases PMo12 and Fe3+ under acidic TME conditions, which are subsequently converted into reduced PMo12 and Fe2+ by GSH in the TME. PMo12 in its reduced state exhibits excellent photothermal conversion efficiency (47.03%) under near-infrared laser irradiation, which boosts the CDT effects by accelerating the reaction between H2O2 and Fe2+ and producing more ˙OH radicals. The resulting PTT/CDT synergistic therapeutic effects are highly dependent on the pH value and GSH concentration in the TME, and exhibit a strong inhibition of HepG2 cell proliferation compared to monotherapy.

Graphical abstract: GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy

Supplementary files

Article information

Article type
Research Article
Submitted
30 4 2024
Accepted
11 6 2024
First published
11 6 2024

Inorg. Chem. Front., 2024,11, 4439-4448

GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy

B. Li, Z. Wu, X. Xu, Y. Lv, Y. Guo, S. Liang, Z. Wang, L. He and Y. Song, Inorg. Chem. Front., 2024, 11, 4439 DOI: 10.1039/D4QI01079E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements