Issue 4, 2024

“Clickable” graphene nanoribbons for biosensor interfaces

Abstract

We report on the synthesis of “clickable” graphene nanoribbons (GNRs) and their application as a versatile interface for electrochemical biosensors. GNRs are successfully deposited on gold-coated working electrodes and serve as a platform for the covalent anchoring of a bioreceptor (i.e., a DNA aptamer), enabling selective and sensitive detection of Interleukin 6 (IL6). Moreover, when applied as the intermediate linker on reduced graphene oxide (rGO)-based field-effect transistors (FETs), the GNRs provide improved robustness compared to conventional aromatic bi-functional linker molecules. GNRs enable an orthogonal and covalent attachment of a recognition unit with a considerably higher probe density than previously established methods. Interestingly, we demonstrate that GNRs introduce photoluminescence (PL) when applied to rGO-based FETs, paving the way toward the simultaneous optical and electronic probing of the attached biointerface.

Graphical abstract: “Clickable” graphene nanoribbons for biosensor interfaces

Supplementary files

Article information

Article type
Communication
Submitted
28 12 2023
Accepted
05 2 2024
First published
22 2 2024
This article is Open Access
Creative Commons BY license

Nanoscale Horiz., 2024,9, 598-608

“Clickable” graphene nanoribbons for biosensor interfaces

R. Hasler, G. E. Fenoy, A. Götz, V. Montes-García, C. Valentini, Z. Qiu, C. Kleber, P. Samorì, K. Müllen and W. Knoll, Nanoscale Horiz., 2024, 9, 598 DOI: 10.1039/D3NH00590A

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