Issue 7, 2024

Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

Abstract

Metal–organic frameworks (MOFs), a burgeoning class of coordination polymers, have garnered significant attention due to their outstanding structure, porosity, and stability. They have been extensively studied in catalysis, energy storage, water harvesting, selective gas separation, and electrochemical applications. Recent advancements in post-synthetic strategies, surface functionality, and biocompatibility have expanded the application scope of MOFs, particularly in various biomedical fields. Herein, we review MOF-based nanomaterials bioimaging nanoplatforms in magnetic resonance imaging, computed tomography, and fluorescence imaging. MOFs serve as the foundation for biosensors, demonstrating efficiency in sensing H2O2, tumor biomarkers, microRNA, and living cancer cells. MOF-based carriers are well designed in drug delivery systems and anticancer treatment therapies. Additionally, we examine the challenges and prospects of MOFs in surface modification, release of metal ions, and interaction with intracellular components, as well as their toxicity and long-term effects.

Graphical abstract: Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

Article information

Article type
Review Article
Submitted
03 12 2023
Accepted
24 1 2024
First published
06 3 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2024,6, 1800-1821

Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

N. T. T. Nguyen, T. T. T. Nguyen, S. Ge, R. K. Liew, D. T. C. Nguyen and T. V. Tran, Nanoscale Adv., 2024, 6, 1800 DOI: 10.1039/D3NA01075A

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