Issue 2, 2024

Structural DNA nanotechnology at the nexus of next-generation bio-applications: challenges and perspectives

Abstract

DNA nanotechnology has significantly progressed in the last four decades, creating nucleic acid structures widely used in various biological applications. The structural flexibility, programmability, and multiform customization of DNA-based nanostructures make them ideal for creating structures of all sizes and shapes and multivalent drug delivery systems. Since then, DNA nanotechnology has advanced significantly, and numerous DNA nanostructures have been used in biology and other scientific disciplines. Despite the progress made in DNA nanotechnology, challenges still need to be addressed before DNA nanostructures can be widely used in biological interfaces. We can open the door for upcoming uses of DNA nanoparticles by tackling these issues and looking into new avenues. The historical development of various DNA nanomaterials has been thoroughly examined in this review, along with the underlying theoretical underpinnings, a summary of their applications in various fields, and an examination of the current roadblocks and potential future directions.

Graphical abstract: Structural DNA nanotechnology at the nexus of next-generation bio-applications: challenges and perspectives

Article information

Article type
Review Article
Submitted
27 8 2023
Accepted
15 12 2023
First published
19 12 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2024,6, 386-401

Structural DNA nanotechnology at the nexus of next-generation bio-applications: challenges and perspectives

S. Kosara, R. Singh and D. Bhatia, Nanoscale Adv., 2024, 6, 386 DOI: 10.1039/D3NA00692A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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