Issue 6, 2024

(Poly)phenol-related gut metabotypes and human health: an update

Abstract

Dietary (poly)phenols have received great interest due to their potential role in the prevention and management of non-communicable diseases. In recent years, a high inter-individual variability in the biological response to (poly)phenols has been demonstrated, which could be related to the high variability in (poly)phenol gut microbial metabolism existing within individuals. An interplay between (poly)phenols and the gut microbiota exists, with (poly)phenols being metabolised by the gut microbiota and their metabolites modulating gut microbiota diversity and composition. A number of (poly)phenol metabolising phenotypes or metabotypes have been proposed, however, potential metabotypes for most (poly)phenols have not been investigated, and the relationship between metabotypes and human health remains ambiguous. This review presents updated knowledge on the reciprocal interaction between (poly)phenols and the gut microbiome, associated gut metabotypes, and subsequent impact on human health.

Graphical abstract: (Poly)phenol-related gut metabotypes and human health: an update

Article information

Article type
Review Article
Submitted
09 10 2023
Accepted
18 2 2024
First published
19 2 2024
This article is Open Access
Creative Commons BY-NC license

Food Funct., 2024,15, 2814-2835

(Poly)phenol-related gut metabotypes and human health: an update

J. Hu, R. Mesnage, K. Tuohy, C. Heiss and A. Rodriguez-Mateos, Food Funct., 2024, 15, 2814 DOI: 10.1039/D3FO04338J

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