Issue 8, 2024

Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

Abstract

Self-assembled monolayers (SAMs) represent highly ordered molecular materials with versatile biochemical features and multidisciplinary applications. Research on SAMs has made much progress since the early begginings of Au substrates and alkanethiols, and numerous examples of peptide-displaying SAMs can be found in the literature. Peptides, presenting increasing structural complexity, stimuli-responsiveness, and biological relevance, represent versatile functional components in SAMs-based platforms. This review examines the major findings and progress made on the use of peptide building blocks displayed as part of SAMs with specific functions, such as selective cell adhesion, migration and differentiation, biomolecular binding, advanced biosensing, molecular electronics, antimicrobial, osteointegrative and antifouling surfaces, among others. Peptide selection and design, functionalisation strategies, as well as structural and functional characteristics from selected examples are discussed. Additionally, advanced fabrication methods for dynamic peptide spatiotemporal presentation are presented, as well as a number of characterisation techniques. All together, these features and approaches enable the preparation and use of increasingly complex peptide-based SAMs to mimic and study biological processes, and provide convergent platforms for high throughput screening discovery and validation of promising therapeutics and technologies.

Graphical abstract: Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

Article information

Article type
Review Article
Submitted
23 10 2023
First published
08 3 2024
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2024,53, 3714-3773

Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

C. Redondo-Gómez, P. Parreira, M. C. L. Martins and H. S. Azevedo, Chem. Soc. Rev., 2024, 53, 3714 DOI: 10.1039/D3CS00921A

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