Issue 7, 2024

Recent advances in Rh(i)-catalyzed enantioselective C–H functionalization

Abstract

Chiral carbon–carbon (C–C) and carbon–heteroatom (C–X) bonds are pervasive and very essential in natural products, bioactive molecules, and functional materials, and their catalytic construction has emerged as one of the hottest research fields in synthetic organic chemistry. The last decade has witnessed vigorous progress in Rh(I)-catalyzed asymmetric C–H functionalization as a complement to Rh(II) and Rh(III) catalysis. This review aims to provide the most comprehensive and up-to-date summary covering the recent advances in Rh(I)-catalyzed C–H activation for asymmetric functionalization. In addition to the development of diverse reactions, chiral ligand design and mechanistic investigation (inner-sphere mechanism, outer-sphere mechanism, and 1,4-Rh migration) will also be highlighted.

Graphical abstract: Recent advances in Rh(i)-catalyzed enantioselective C–H functionalization

Article information

Article type
Review Article
Submitted
12 9 2023
First published
27 2 2024
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2024,53, 3457-3484

Recent advances in Rh(I)-catalyzed enantioselective C–H functionalization

Y. Zhang, J. Zhang, L. Lou, R. Lin, N. Cramer, S. Wang and Z. Chen, Chem. Soc. Rev., 2024, 53, 3457 DOI: 10.1039/D3CS00762F

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