Issue 41, 2024

Fluorescent coumarin-alkynes for labeling of amino acids and peptides via manganese(i)-catalyzed C–H alkenylation

Abstract

The late-stage fluorescent labeling of structurally complex peptides bears immense potential for molecular imaging. Herein, we report on a manganese(I)-catalyzed peptide C–H alkenylation under exceedingly mild conditions with natural fluorophores as coumarin- and chromone-derivatives. The robustness and efficiency of the manganese(I) catalysis regime was reflected by a broad functional group tolerance and low catalyst loading in a resource- and atom-economical fashion.

Graphical abstract: Fluorescent coumarin-alkynes for labeling of amino acids and peptides via manganese(i)-catalyzed C–H alkenylation

Supplementary files

Article information

Article type
Communication
Submitted
24 1 2024
Accepted
19 4 2024
First published
22 4 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 5423-5426

Fluorescent coumarin-alkynes for labeling of amino acids and peptides via manganese(I)-catalyzed C–H alkenylation

A. Kopp, T. Oyama and L. Ackermann, Chem. Commun., 2024, 60, 5423 DOI: 10.1039/D4CC00361F

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