Issue 37, 2023

Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

Abstract

Carbon dot (CD)-based nanozymes have great potential in antibacterial applications. In order to achieve enhanced broad-spectrum antibacterial capacity, we synthesized Co-doped drug-based CDs (Co-Lvx-CDs) using levofloxacin and vitamin B12 as precursors by mimicking the catalysis of antibacterial activity of natural enzymes. The Co-Lvx-CDs retained not only the effective functional groups of the traditional antibiotic levofloxacin but also achieved oxidase-like and peroxidase-like activities to generate reactive oxygen species (ROS) through Co doping. Additionally, the Co-Lvx-CDs had superb fluorescence properties and could be applied in information encryption. The CDs were validated to have a broad-spectrum bactericidal effect against Gram-positive and -negative bacteria, compensating for the limitations of levofloxacin while also having enhanced sterilization ability. Importantly, the proposed Co-Lvx-CDs provide a new idea for the design of multifunctional CD-based nanozymes with preconceived outcomes.

Graphical abstract: Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

Supplementary files

Article information

Article type
Paper
Submitted
17 6 2023
Accepted
25 7 2023
First published
26 7 2023

J. Mater. Chem. B, 2023,11, 8916-8925

Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

G. Niu, F. Gao, C. Li, Y. Wang, H. Li and Y. Jiang, J. Mater. Chem. B, 2023, 11, 8916 DOI: 10.1039/D3TB01376F

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