Issue 25, 2023

Synergistic antibacterial action of lignin-squaraine hybrid photodynamic therapy: advancing towards effective treatment of antibiotic-resistant bacteria

Abstract

Antibacterial photodynamic therapy (aPDT) is emerging as an effective means of treating pathogenic bacteria, especially in light of the challenges posed by antibiotic resistance. SQR29, an organophotosensitizer, was encapsulated in a poly(lignin/PEG/PPG urethane) hydrogel to enable targeted treatment at a specific infected area. The hydrogel exhibited free radical scavenging properties which were effective in preventing oxidative stress and promoted wound healing. The hydrogel exhibited a significant aPDT effect on Gram-positive bacteria, hence showing its potential in combating antibiotic-resistant pathogenic bacteria in chronic wound infection.

Graphical abstract: Synergistic antibacterial action of lignin-squaraine hybrid photodynamic therapy: advancing towards effective treatment of antibiotic-resistant bacteria

Supplementary files

Article information

Article type
Communication
Submitted
24 3 2023
Accepted
25 5 2023
First published
25 5 2023
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2023,11, 5748-5751

Synergistic antibacterial action of lignin-squaraine hybrid photodynamic therapy: advancing towards effective treatment of antibiotic-resistant bacteria

Ferdinandus, C. Joo, D. Kai and C. K. Lee, J. Mater. Chem. B, 2023, 11, 5748 DOI: 10.1039/D3TB00629H

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