Issue 17, 2023

The memory effect of micro/nano-structures activating osteogenic differentiation of BMSCs

Abstract

Degradable bioceramics such as hydroxyapatite (HA) are usually used as bone grafts due to their excellent osteoconductive ability. Recent studies have proved that decorated micro/nano-structures on HA could enhance its osteogenic capacity by directly activating osteogenic differentiation of bone marrow-derived stem cells (BMSCs) or by indirectly activating the osteoimmune microenvironment. However, it is still unclear whether the degradation process of HA affects the activation effect of micro/nano-structures. In this study, we first demonstrate that the enhanced osteogenic properties activated by micro/nano-structures could be memorized and continue to play a role even after the removal of micro/nano-structures. More interestingly, this topography-triggered osteogenic memory effect (TTOME) could be regulated through the stimulation time, indicating the importance of the rational maintenance of micro/nano-structures as well as the degradation process of bioceramics. These findings provide a perspective of the design of bone implants with a biodegradable surface topography.

Graphical abstract: The memory effect of micro/nano-structures activating osteogenic differentiation of BMSCs

Article information

Article type
Paper
Submitted
16 2 2023
Accepted
03 4 2023
First published
06 4 2023
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2023,11, 3816-3822

The memory effect of micro/nano-structures activating osteogenic differentiation of BMSCs

C. Zhao, C. Yang, Q. Lou, J. Yan, X. Wang and J. Chang, J. Mater. Chem. B, 2023, 11, 3816 DOI: 10.1039/D3TB00337J

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