Issue 24, 2023

Choline phosphate lipid-hitchhiked near-infrared BODIPY nanoparticles for enhanced phototheranostics

Abstract

Phototheranostics integrating optical imaging and phototherapy has attracted extensive attention. Achieving nanophototherapeutics with near infrared (NIR)-light synchronously triggered photodynamic therapy (PDT) and photothermal therapy (PTT) is challenging. Herein, we develop a multifunctional theranostic nanoplatform prepared from the co-assembly of NIR boron dipyrromethene (BODIPY) with a cooperative D–π–A structure of a thiophene-BODIPY core and benzene-diethylamino, and a choline phosphate lipid. The as-fabricated nanoparticles (DBNPs) exhibited desirable NIR absorption, uniform spherical morphology and good colloidal stability. The elaborate molecular design and supramolecular assembly endowed DBNPs with desirable PDT and PTT activities. Upon 808 nm laser irradiation, the DBNPs efficiently generated active singlet oxygen and regional hyperpyrexia, with a photothermal conversion efficiency of 37.6%. The excellent PDT and PTT performance of DBNPs boosted the potent in vitro and in vivo anti-tumor effects. In addition, these nanoparticles manifested their good capability of NIR fluorescence imaging of tumors. Overall, the DBNPs provide a paradigm for delivering hydrophobic phototherapy molecules with phospholipids for enhanced tumor treatment and imaging.

Graphical abstract: Choline phosphate lipid-hitchhiked near-infrared BODIPY nanoparticles for enhanced phototheranostics

Supplementary files

Article information

Article type
Paper
Submitted
29 1 2023
Accepted
21 4 2023
First published
24 4 2023
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2023,11, 5586-5593

Choline phosphate lipid-hitchhiked near-infrared BODIPY nanoparticles for enhanced phototheranostics

H. Geng, W. Lin, J. Liu, Q. Pei and Z. Xie, J. Mater. Chem. B, 2023, 11, 5586 DOI: 10.1039/D3TB00175J

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