Issue 1, 2023

Effect of mussel-inspired polydopamine on the reinforced properties of 3D printed β-tricalcium phosphate/polycaprolactone scaffolds for bone regeneration

Abstract

Bioceramic/polymer scaffolds have been considered as potential grafts used for facilitating bone healing. Unfortunately, the poor interfacial interaction between polymer matrices and bioceramic fillers limited their use in practical medicine. Thus, a facile strategy for reinforcing the three-dimensional printed β-tricalcium phosphate/polycaprolactone scaffolds through employing polydopamine modified-ceramics as fillers. The effects of the dopamine precursor on the compressive strength, degradability, cell proliferation, osteogenic differentiation, and in vivo osteogenicity were measured. The results indicated that the concentration of dopamine could remarkably affect the thickness and density of the polydopamine layer on fillers, further varying the compressive strength (1.23-fold to 1.64-fold), degradability, and osteogenicity of the scaffolds. More importantly, the presence of polydopamine in the three-dimensional printed composite scaffolds not only facilitated the proliferation, alkaline phosphatase activity and mineralization of mesenchymal stem cells, but also stimulated the formation of neo-bone tissue in femur defects. Taking together, the proposed scaffolds might serve as a candidate for bone regeneration.

Graphical abstract: Effect of mussel-inspired polydopamine on the reinforced properties of 3D printed β-tricalcium phosphate/polycaprolactone scaffolds for bone regeneration

Article information

Article type
Paper
Submitted
20 9 2022
Accepted
01 11 2022
First published
01 11 2022

J. Mater. Chem. B, 2023,11, 72-82

Effect of mussel-inspired polydopamine on the reinforced properties of 3D printed β-tricalcium phosphate/polycaprolactone scaffolds for bone regeneration

C. Ho, Y. Chen, K. Wang, Y. Lin, T. Chen and M. Shie, J. Mater. Chem. B, 2023, 11, 72 DOI: 10.1039/D2TB01995G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements