Issue 45, 2023

Surface-enhanced Raman scattering sensing for detection and mapping of key cellular biomarkers

Abstract

Cellular biomarkers mainly contain proteins, nucleic acids, glycans and many small molecules including small biomolecule metabolites, reactive oxygen species and other cellular chemical entities. The detection and mapping of the key cellular biomarkers can effectively help us to understand important cellular mechanisms associated with physiological and pathological processes, which greatly promote the development of clinical diagnosis and disease treatment. Surface-enhanced Raman scattering (SERS) possesses high sensitivity and is free from the influence of strong self-fluorescence in living systems as well as the photobleaching of the dyes. It exhibits rich and narrow chemical fingerprint spectra for multiplexed detection, and has become a powerful tool to detect and map cellular biomarkers. In this review, we present an overview of recent advances in the detection and mapping of different classes of cellular biomarkers based on SERS sensing. These advances fully confirm that the SERS-based sensors and sensing methods have great potential for the exploration of biological mechanisms and clinical applications. Additionally, we also discuss the limitations of present research and the future developments of the SERS technology in this field.

Graphical abstract: Surface-enhanced Raman scattering sensing for detection and mapping of key cellular biomarkers

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Article information

Article type
Review Article
Submitted
03 9 2023
Accepted
20 10 2023
First published
25 10 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 12869-12882

Surface-enhanced Raman scattering sensing for detection and mapping of key cellular biomarkers

Y. Yang, S. Wu, Y. Chen and H. Ju, Chem. Sci., 2023, 14, 12869 DOI: 10.1039/D3SC04650H

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