Issue 46, 2023

Advancing cell surface modification in mammalian cells with synthetic molecules

Abstract

Biological cells, being the fundamental entities of life, are widely acknowledged as intricate living machines. The manipulation of cell surfaces has emerged as a progressively significant domain of investigation and advancement in recent times. Particularly, the alteration of cell surfaces using meticulously crafted and thoroughly characterized synthesized molecules has proven to be an efficacious means of introducing innovative functionalities or manipulating cells. Within this realm, a diverse array of elegant and robust strategies have been recently devised, including the bioorthogonal strategy, which enables selective modification. This review offers a comprehensive survey of recent advancements in the modification of mammalian cell surfaces through the use of synthetic molecules. It explores a range of strategies, encompassing chemical covalent modifications, physical alterations, and bioorthogonal approaches. The review concludes by addressing the present challenges and potential future opportunities in this rapidly expanding field.

Graphical abstract: Advancing cell surface modification in mammalian cells with synthetic molecules

Article information

Article type
Review Article
Submitted
31 8 2023
Accepted
30 10 2023
First published
10 11 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 13325-13345

Advancing cell surface modification in mammalian cells with synthetic molecules

H. Yang, L. Yao, Y. Wang, G. Chen and H. Chen, Chem. Sci., 2023, 14, 13325 DOI: 10.1039/D3SC04597H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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