Issue 31, 2023

Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis

Abstract

Hydride transfer (HT) is a fundamental step in a wide range of reaction pathways, including those mediated by dihydropyridinates (DHPs). Coordination of ions directly to the pyridine ring or functional groups stemming therefrom, provides a powerful approach for influencing the electronic structure and in turn HT chemistry. Much of the work in this area is inspired by the chemistry of bioinorganic systems including NADH. Coordination of metal ions to pyridines lowers the electron density in the pyridine ring and lowers the reduction potential: lower-energy reactions and enhanced selectivity are two outcomes from these modifications. Herein, we discuss approaches for the preparation of DHP–metal complexes and selected examples of their reactivity. We suggest further areas in which these metallated DHPs could be developed and applied in synthesis and catalysis.

Graphical abstract: Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis

Article information

Article type
Perspective
Submitted
22 4 2023
Accepted
14 7 2023
First published
17 7 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 8234-8248

Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis

L. W. T. Parsons and L. A. Berben, Chem. Sci., 2023, 14, 8234 DOI: 10.1039/D3SC02080K

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