Issue 17, 2023

Streamlining the interface between electronics and neural systems for bidirectional electrochemical communication

Abstract

Seamless neural interfaces conjoining neurons and electrochemical devices hold great potential for highly efficient signal transmission across neural systems and the external world. Signal transmission through chemical sensing and stimulation via electrochemistry is remarkable because communication occurs through the same chemical language of neurons. Emerging strategies based on synaptic interfaces, iontronics-based neuromodulation, and improvements in selective neurosensing techniques have been explored to achieve seamless integration and efficient neuro-electronics communication. Synaptic interfaces can directly exchange signals to and from neurons, in a similar manner to that of chemical synapses. Hydrogel-based iontronic chemical delivery devices are operationally compatible with neural systems for improved neuromodulation. In this perspective, we explore developments to improve the interface between neurons and electrodes by targeting neurons or sub-neuronal regions including synapses. Furthermore, recent progress in electrochemical neurosensing and iontronics-based chemical delivery is examined.

Graphical abstract: Streamlining the interface between electronics and neural systems for bidirectional electrochemical communication

Article information

Article type
Perspective
Submitted
19 1 2023
Accepted
13 4 2023
First published
14 4 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 4463-4479

Streamlining the interface between electronics and neural systems for bidirectional electrochemical communication

W. Cho, S. Yoon and T. D. Chung, Chem. Sci., 2023, 14, 4463 DOI: 10.1039/D3SC00338H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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