Issue 13, 2023

Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

Abstract

Bacteria resistant to antibiotics present a threat to public health. The bacterial non-2-ulosonic acids, including pseudaminic acid, legionaminic acid, acinetaminic acid, fusaminic acid, and several of their epimers, have been identified from the pathogenic Gram-negative bacteria, which have been proposed to associate with bacterial infection/pathogenicity, immune escape, and so on. The intriguing structures and less-understood biological functions make them attractive synthetic targets for biological studies and drug discovery. In this review, the chemical syntheses of four types of non-2-ulosonic acid structures that were reported in the past two decades are summarised, together with recent progress on the application of synthetic non-2-ulosonic acid derivatives.

Graphical abstract: Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

Supplementary files

Article information

Article type
Review Article
Submitted
28 4 2023
Accepted
29 5 2023
First published
02 6 2023

Org. Chem. Front., 2023,10, 3429-3446

Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

X. Guo, P. Li, H. Liu and X. Li, Org. Chem. Front., 2023, 10, 3429 DOI: 10.1039/D3QO00637A

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