Issue 22, 2023

Dithiocarbazate–Zn(ii) complexes for photodynamic therapy and chemotherapy against lung cancer

Abstract

Combining photodynamic therapy with chemotherapy is a promising strategy for treating tumors. Herein, a series of new dithiocarbazate–Zn(II) complexes, including [ZnII(L1)2] Zn1, [ZnII(L2)2] Zn2, [ZnII(L3)2] Zn3, and [ZnII(L4)2] Zn4, have been synthesized for chemotherapy and photodynamic therapy of lung cancer. These complexes can be used for live-cell fluorescence-based imaging, are photostable, and exhibit hemolysis comparable to cisplatin. Among them, complex Zn3 shows good chemotherapeutic ability, and its chemotherapeutic mechanism relies on multiple pathways. At the same time, complex Zn3 generates superoxide anion radicals (˙O2) under light irradiation, leading to cancer cell death through photodynamic therapy. Its remarkable anticancer effect is achieved through multimodal photodynamic therapy/chemotherapy. This study paves the way for the use of novel Zn(II) complexes as anticancer agents, providing new strategies for multimodal cancer therapy.

Graphical abstract: Dithiocarbazate–Zn(ii) complexes for photodynamic therapy and chemotherapy against lung cancer

Supplementary files

Article information

Article type
Research Article
Submitted
04 9 2023
Accepted
19 9 2023
First published
20 9 2023

Inorg. Chem. Front., 2023,10, 6526-6536

Dithiocarbazate–Zn(II) complexes for photodynamic therapy and chemotherapy against lung cancer

J. Deng, Y. Wu, A. Li, W. Pan, L. Hou, D. Wu, Z. Zhang, F. Yang and Y. Gou, Inorg. Chem. Front., 2023, 10, 6526 DOI: 10.1039/D3QI01777J

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