Issue 47, 2023

Inducing tumor ferroptosis via a pH-responsive NIR-II photothermal agent initiating lysosomal dysfunction

Abstract

Ferroptosis is a unique programmed cell death process that was discovered a few years ago and plays an important role in tumor biology and treatment. However, it still remains a challenge to modulate tumor ferroptosis by spatiotemporally controlled cell-intrinsic Fenton chemistry. Herein, a pH activated photothermal sensitizer IR-PE has been designed and synthesized on the basis of cyanine bearing a diamine moiety, which is capable of triggering the lysosomal dysfunction-mediated Fenton pathway under the irradiation of near-infrared light to evoke ferroptosis, thereby improving antitumor efficacy and mitigating systemic side effects.

Graphical abstract: Inducing tumor ferroptosis via a pH-responsive NIR-II photothermal agent initiating lysosomal dysfunction

Supplementary files

Article information

Article type
Communication
Submitted
17 8 2023
Accepted
23 10 2023
First published
06 11 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2023,15, 19074-19078

Inducing tumor ferroptosis via a pH-responsive NIR-II photothermal agent initiating lysosomal dysfunction

Z. Zhang, J. Xiang, L. Guan, P. Chen, C. Li, C. Guo, Y. Hu, S. Huang, L. Cai and P. Gong, Nanoscale, 2023, 15, 19074 DOI: 10.1039/D3NR04124G

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