Issue 42, 2023

Nanozymes with versatile redox capabilities inspired in metalloenzymes

Abstract

Metalloenzymes represent exemplary systems in which an organic scaffold combines with a functional inorganic entity, resulting in excellent redox catalysts. Inspired by these natural hybrid biomolecules, biomolecular templates have garnered significant attention for the controlled synthesis of inorganic nanostructures. These nanostructures ultimately benefit from the protection and colloidal stabilization provided by the biomacromolecule. In this study, we have employed this strategy to prepare nanozymes with redox capabilities, utilizing the versatile catalytic profile of Pt-loaded nanomaterials. Thus, we have investigated protein-templated Pt-based nanoclusters of different sizes and compositions, which exhibit remarkable oxidase, catalase, and reductase-like activities. The interplay between the composition and catalytic activity highlighted the size of the nanocluster as the most prominent factor in determining the performance of the nanozymes. Additionally, we have demonstrated the use of protein-templated nanozymes as potential co-catalysts in combination with enzymes for coupled reactions, under both sequential and concurrent one-pot conditions. This study provides valuable insights into nanozyme design and its wide range of applications in the design of complex catalytic systems.

Graphical abstract: Nanozymes with versatile redox capabilities inspired in metalloenzymes

Supplementary files

Article information

Article type
Paper
Submitted
14 7 2023
Accepted
24 9 2023
First published
02 10 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2023,15, 16959-16966

Nanozymes with versatile redox capabilities inspired in metalloenzymes

R. López-Domene, K. Kumar, J. E. Barcelon, G. Guedes, A. Beloqui and A. L. Cortajarena, Nanoscale, 2023, 15, 16959 DOI: 10.1039/D3NR03443G

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