Issue 11, 2023

Specific interaction based drug loading strategies

Abstract

Drug carriers have been commonly used for drug control release, enhancing drug efficacy and/or minimizing side-effects. However, it is still difficult to get a high loading efficiency when encapsulating super hydrophilic drugs with a narrow therapeutic index, such as many neurotoxins. Increasing the carrier proportion can improve drug loading to a certain degree, while the burst released drug when the formulation enters the body may cause overdose side-effects. Moreover, high-dose carriers themselves may increase the metabolic burden of the body. Hence, new drug carriers and/or loading strategies are urgently needed to promote the applications of these drugs. This minireview will introduce drug loading strategies based on specific interactions (between drugs and carriers) and will discuss the challenges and perspectives of these strategies. This work is expected to provide alternative inspiration for the delivery of hydrophilic drugs.

Graphical abstract: Specific interaction based drug loading strategies

Article information

Article type
Minireview
Submitted
29 4 2023
Accepted
01 8 2023
First published
04 8 2023

Nanoscale Horiz., 2023,8, 1523-1528

Specific interaction based drug loading strategies

H. Yu, S. Zhang, H. Yang, J. Miao, X. Ma, W. Xiong, G. Chen and T. Ji, Nanoscale Horiz., 2023, 8, 1523 DOI: 10.1039/D3NH00165B

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