Issue 4, 2023

Low-density lipoprotein: a versatile nanoscale platform for targeted delivery

Abstract

Low-density lipoprotein (LDL) is a small lipoprotein that plays a vital role in controlling lipid metabolism. LDL has a delicate nanostructure with unique physicochemical properties: superior payload capacity, long residence time in circulation, excellent biocompatibility, smaller size, and natural targeting. In recent decades, the superiority and feasibility of LDL particles as targeted delivery carriers have attracted much attention. In this review, we introduce the structure, composition, advantages, defects, and reconstruction of LDL delivery systems, summarize their research status and progress in targeted diagnosis and therapy, and finally look forward to the clinical application of LDL as an effective delivery vehicle.

Graphical abstract: Low-density lipoprotein: a versatile nanoscale platform for targeted delivery

Article information

Article type
Review Article
Submitted
02 12 2022
Accepted
06 1 2023
First published
24 1 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 1011-1022

Low-density lipoprotein: a versatile nanoscale platform for targeted delivery

L. Dai, S. Li, Q. Hao, R. Zhou, H. Zhou, W. Lei, H. Kang, H. Wu, Y. Li and X. Ma, Nanoscale Adv., 2023, 5, 1011 DOI: 10.1039/D2NA00883A

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