Issue 5, 2023

Recent trends in emerging strategies for ferroptosis-based cancer therapy

Abstract

Ferroptosis, an iron-dependent mode of regulated cell death, is induced by lipid peroxidation, whose occurrence and execution are primarily controlled by metabolism of iron, lipids, amino acids and glutathione. In recent years, the fast-growing studies of ferroptosis in cancer have promoted its application in cancer therapy. So, this review focuses on the feasibility and characteristics of initiating ferroptosis for cancer therapy, as well as the main mechanism of ferroptosis. And various emerging strategies of cancer therapy based on ferroptosis are then highlighted to describe their design, mechanism of action, and anticancer applications. In addition ferroptosis in diverse cancer types is summarized, some considerations for the research of various preparations that can cause ferroptosis are introduced, and this emerging field is discussed in terms of its challenges and future development directions.

Graphical abstract: Recent trends in emerging strategies for ferroptosis-based cancer therapy

Article information

Article type
Review Article
Submitted
18 10 2022
Accepted
31 1 2023
First published
14 2 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 1271-1290

Recent trends in emerging strategies for ferroptosis-based cancer therapy

H. Yu, J. Yan, Z. Li, L. Yang, F. Ju and Y. Sun, Nanoscale Adv., 2023, 5, 1271 DOI: 10.1039/D2NA00719C

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