Issue 9, 2023

In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy

Abstract

Advanced elastomers are highly in demand for the fabrication of medical devices for minimally invasive surgery (MIS). Herein, a shape memory and self-healing polyurethane (PCLUSe) composed of semi-crystalline poly(ε-caprolactone) (PCL) segments and interchangeable and antioxidative diselenide bonds was designed and synthesized. The excellent shape memory of PCLUSe contributed to the smooth MIS operation, leading to less surgical wounds than in the case of sternotomy. The diselenide bonds of PCLUSe contributed to the rapid self-healing under 405 nm irradiation within 60 s, and the alleviation of tissue oxidation post injury. After being delivered through a 10 mm diameter trocar onto a beating canine heart by MIS, two shape-recovered PCLUSe films self-assembled (self-healing) into a larger single patch (20 × 10 × 0.2 mm3) under the trigger of laser irradiation in situ, which could efficiently overcome the limited-size problem within MIS and meet a larger treatment area. The diselenide bonds in the PCLUSe cardiac patches protected the myocardium under oxidative stress post myocardial infarction (MI), and significantly maintained the cardiac functions.

Graphical abstract: In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy

Supplementary files

Article information

Article type
Communication
Submitted
19 4 2023
Accepted
28 6 2023
First published
28 6 2023

Mater. Horiz., 2023,10, 3438-3449

In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy

S. Li, H. Zhang, J. Xie, Z. Wang, K. Wang, Z. Zhai, J. Ding, S. Wang, L. Shen, J. Wen, Y. Tang, H. Wang, Y. Zhu and C. Gao, Mater. Horiz., 2023, 10, 3438 DOI: 10.1039/D3MH00594A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements