Issue 9, 2023

Molecularly or atomically precise nanostructures for bio-applications: how far have we come?

Abstract

A huge variety of nanostructures are promising for biomedical applications, but only a few have been practically applied. Among the various reasons, the limited structural preciseness is a critical one, as it increases the difficulty in product quality control, accurate dosing, and ensuring the repeatability of material performance. Constructing nanoparticles with molecule-like preciseness is becoming a new research field. In this review, we focus on the artificial nanomaterials that can currently be molecularly or atomically precise, including DNA nanostructures, some metallic nanoclusters, dendrimer nanoparticles and carbon nanostructures, describing their syntheses, bio-applications and limitations, in view of up-to-date studies. A perspective on their potential for clinical translation is also given. This review is expected to provide a particular rationale for the future design of nanomedicines.

Graphical abstract: Molecularly or atomically precise nanostructures for bio-applications: how far have we come?

Article information

Article type
Review Article
Submitted
17 4 2023
Accepted
09 6 2023
First published
09 6 2023

Mater. Horiz., 2023,10, 3304-3324

Molecularly or atomically precise nanostructures for bio-applications: how far have we come?

J. Wang, P. Li, C. Wang, N. Liu and D. Xing, Mater. Horiz., 2023, 10, 3304 DOI: 10.1039/D3MH00574G

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