Issue 14, 2023

Scalable production of microscopic particles for biological delivery

Abstract

Microscopic particles (nano- and micro-particles) have shown great potential as biological delivery carriers, with notable success stories such as in DOXIL and COVID-19 vaccines. Translation of these advanced drug delivery systems to industry/clinic is challenging, with scalable production being one of the keys. This review summarizes efforts in the literature in developing scalable production processes for microscopic particle-based bio-delivery systems. These scalable production processes include both batch processes and continuous processes such as microfluidics, flash technology, and electrospray. The materials used for particle-based delivery carriers include organic, inorganic, as well as hybrid materials. Finally, we also discuss the downstream processes after production, e.g., purification, bioconjugation, sterilization, and storage.

Graphical abstract: Scalable production of microscopic particles for biological delivery

Article information

Article type
Review Article
Submitted
12 1 2023
Accepted
12 6 2023
First published
16 6 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2023,4, 2885-2908

Scalable production of microscopic particles for biological delivery

H. Lin, J. Leng, P. Fan, Z. Xu and G. Ruan, Mater. Adv., 2023, 4, 2885 DOI: 10.1039/D3MA00021D

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