Issue 5, 2023

Decarboxylative arylation with diaryliodonium(iii) salts: alternative approach for catalyst-free difluoroenolate coupling to aryldifluoromethyl ketones

Abstract

Catalyst-free access to aryldifluoromethyl ketones has been achieved through decarboxylative arylation of α,α-difluoro-β-ketoacid salts using diaryliodonium(III) salts. The products were successfully transformed into the corresponding esters, amides, and difluoromethyl compounds. This strategy provides access to fluorine-containing drugs, thus contributing to drug design.

Graphical abstract: Decarboxylative arylation with diaryliodonium(iii) salts: alternative approach for catalyst-free difluoroenolate coupling to aryldifluoromethyl ketones

Supplementary files

Article information

Article type
Communication
Submitted
24 11 2022
Accepted
18 1 2023
First published
24 1 2023

Green Chem., 2023,25, 1790-1796

Author version available

Decarboxylative arylation with diaryliodonium(III) salts: alternative approach for catalyst-free difluoroenolate coupling to aryldifluoromethyl ketones

K. Kikushima, K. Yamada, N. Umekawa, N. Yoshio, Y. Kita and T. Dohi, Green Chem., 2023, 25, 1790 DOI: 10.1039/D2GC04445E

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