Issue 44, 2023

Recent advances in the nanoarchitectonics of metal–organic frameworks for light-activated tumor therapy

Abstract

Metal–organic frameworks (MOFs) have received extensive attention in tumor therapy because of their advantages, including large specific surface area, regular pore size, adjustable shape, and facile functionalization. MOFs are porous materials formed by the coordination bonding of metal clusters and organic ligands. This review summarized the most recent advancements in tumor treatment based on nMOFs. First, we discuss the classification of MOFs, which primarily include the series of isoreticular MOF (IRMOF), zeolitic imidazolate framework (ZIF), coordination pillared-layer (CPL), Materials of Institute Lavoisier (MIL), porous coordination network (PCN), University of Oslo (UiO) and Biological metal–organic frameworks (BioMOFs). Then, we discuss the use of nMOFs in antitumor therapy, including drug delivery strategies, photodynamic therapy (PDT), photothermal therapy (PTT), and combination therapy. Finally, the obstacles and opportunities in nMOFs are discussed.

Graphical abstract: Recent advances in the nanoarchitectonics of metal–organic frameworks for light-activated tumor therapy

Article information

Article type
Perspective
Submitted
22 8 2023
Accepted
19 9 2023
First published
26 9 2023

Dalton Trans., 2023,52, 16085-16102

Recent advances in the nanoarchitectonics of metal–organic frameworks for light-activated tumor therapy

H. Duan, F. Wang, W. Xu, G. Sheng, Z. Sun and H. Chu, Dalton Trans., 2023, 52, 16085 DOI: 10.1039/D3DT02725B

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