Issue 12, 2023

The effect of size, shape, coating and functionalization on nuclear relaxation properties in iron oxide core–shell nanoparticles: a brief review of the situation

Abstract

In this perspective article, we present a short selection of some of the most significant case studies on magnetic nanoparticles for potential applications in nanomedicine, mainly magnetic resonance. For almost 10 years, our research activity focused on the comprehension of the physical mechanisms on the basis of the nuclear relaxation of magnetic nanoparticles in the presence of magnetic fields; taking advantage of the insights gathered over this time span, we report on the dependence of the relaxation behaviour on the chemico-physical properties of magnetic nanoparticles and discuss them in full detail. In particular, a critical review is carried out on the correlations between their efficiency as contrast agents in magnetic resonance imaging and the magnetic core of magnetic nanoparticles (mainly iron oxides), their size and shape, and the coating and solvent used for making them biocompatible and well dispersible in physiological media. Finally, the heuristic model proposed by Roch and coworkers is presented, as it was extensively adopted to describe most of the experimental data sets. The large amount of data analyzed allowed us to highlight both the advantages and limitations of the model.

Graphical abstract: The effect of size, shape, coating and functionalization on nuclear relaxation properties in iron oxide core–shell nanoparticles: a brief review of the situation

Article information

Article type
Perspective
Submitted
18 10 2022
Accepted
17 2 2023
First published
20 2 2023
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2023,52, 3551-3562

The effect of size, shape, coating and functionalization on nuclear relaxation properties in iron oxide core–shell nanoparticles: a brief review of the situation

P. Arosio, F. Orsini, F. Brero, M. Mariani, C. Innocenti, C. Sangregorio and A. Lascialfari, Dalton Trans., 2023, 52, 3551 DOI: 10.1039/D2DT03387A

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