Issue 84, 2023

Aminoalcohol derivatives by nickel-catalyzed enantioselective coupling of imines and dienol ethers

Abstract

The reductive coupling of dienol ethers with N-tosylimines catalyzed by Ni(0) in the presence of a VAPOL-derived phosphoramidite ligand follows an unprecedented regiochemical course; it furnishes syn-configured 1,2-aminoalcohol derivatives in good chemical yields with up to 94% ee.

Graphical abstract: Aminoalcohol derivatives by nickel-catalyzed enantioselective coupling of imines and dienol ethers

Supplementary files

Article information

Article type
Communication
Submitted
15 9 2023
Accepted
28 9 2023
First published
28 9 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 12613-12616

Aminoalcohol derivatives by nickel-catalyzed enantioselective coupling of imines and dienol ethers

J. Y. Kim, T. Q. Davies and A. Fürstner, Chem. Commun., 2023, 59, 12613 DOI: 10.1039/D3CC04582J

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