Issue 93, 2023

Engineering semi-permeable giant liposomes

Abstract

Giant unilamellar vesicles (GUVs) with a semi-permeable nature are prerequisites for constructing synthetic cells. Here we engineer semi-permeable GUVs by the inclusion of DOTAP lipid in vesicles. Diffusion of molecules of different charge and size across GUVs are reported. Control over size-selective permeability is demonstrated by modulating the DOTAP lipid composition in different lipid systems without reconstituting membrane proteins. Such semi-permeable GUVs have immense applications for constructing synthetic cells.

Graphical abstract: Engineering semi-permeable giant liposomes

Supplementary files

Article information

Article type
Communication
Submitted
21 8 2023
Accepted
31 10 2023
First published
31 10 2023

Chem. Commun., 2023,59, 13863-13866

Engineering semi-permeable giant liposomes

S. Radhakrishnan, K. S. Nair, S. Nandi and H. Bajaj, Chem. Commun., 2023, 59, 13863 DOI: 10.1039/D3CC04039A

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