Issue 37, 2023

Frontiers in 19F-MR imaging: nanofluorides and 19F-CEST as novel extensions to the 19F-MRI toolbox

Abstract

Fluorine-containing materials have enriched the field of molecular and cellular MRI with unambiguous and quantitative detection capabilities. The background-free “hot-spot” display and the large range of chemical shifts of the broad palette of 19F-formulations are now used for a variety of applications. The common features of these formulations are: (i) they are based on organic molecular backbones (i.e., organofluorines); and (ii) their 19F-MRI detectability relies on a well-defined and clearly observed 19F-MR signal. During the last few years, our lab aimed to expand the 19F-MR toolbox with new capabilities that were, thus far, not used in molecular and cellular 19F-MRI. This Feature Article summarizes our developments and implementations in the field of 19F-MRI emphasizing (i) the introduction of ultrasmall inorganic fluoride-based nanocrystals (nanofluorides) as nano-sized (<10 nm) agents for 19F-MRI, and (ii) the use of Chemical Exchange Saturation Transfer (CEST) in the 19F-MRI framework to indirectly amplify 19F-MR signals of otherwise-undetected fluorinated entities.

Graphical abstract: Frontiers in 19F-MR imaging: nanofluorides and 19F-CEST as novel extensions to the 19F-MRI toolbox

Article information

Article type
Feature Article
Submitted
07 2 2023
Accepted
04 4 2023
First published
12 4 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 5502-5513

Frontiers in 19F-MR imaging: nanofluorides and 19F-CEST as novel extensions to the 19F-MRI toolbox

A. Galisova and A. Bar-Shir, Chem. Commun., 2023, 59, 5502 DOI: 10.1039/D3CC00562C

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