Issue 17, 2023

Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors

Abstract

Blood glucose (BG) monitoring is critical for diabetes management. In recent years, microneedle (MN)-based technology has attracted emerging attention in glucose sensing and detection. In this review, we summarized MN-based sampling for glucose collection and glucose analysis in detail. First, different principles of MN-based biofluid extraction were elaborated, including external negative pressure, capillary force, swelling force and iontophoresis, which would guide the shape design and material optimization of MNs. Second, MNs coupled with different analysis approaches, including Raman methods, colorimetry, fluorescence, and electrochemical sensing, were emphasized to exhibit the trend towards highly integrated wearable sensors. Finally, the future development prospects of MN-based devices were discussed.

Graphical abstract: Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors

Article information

Article type
Review Article
Submitted
08 3 2023
Accepted
25 6 2023
First published
27 6 2023
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2023,11, 5727-5757

Microneedle-based glucose monitoring: a review from sampling methods to wearable biosensors

Y. Wang, Y. Wu and Y. Lei, Biomater. Sci., 2023, 11, 5727 DOI: 10.1039/D3BM00409K

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