Issue 31, 2022

Tannic acid: a versatile polyphenol for design of biomedical hydrogels

Abstract

Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic acid with several galloyl groups in its structure. Tannic acid interacts with various organic, inorganic, hydrophilic, and hydrophobic materials such as proteins and polysaccharides via hydrogen bonding, electrostatic, coordinative bonding, and hydrophobic interactions. Tannic acid has been studied for various biomedical applications as a natural crosslinker with anti-inflammatory, antibacterial, and anticancer activities. In this review, we focus on TA-based hydrogels for biomaterials engineering to help biomaterials scientists and engineers better realize TA's potential in the design and fabrication of novel hydrogel biomaterials. The interactions of TA with various natural or synthetic compounds are deliberated, discussing parameters that affect TA–material interactions thus providing a fundamental set of criteria for utilizing TA in hydrogels for tissue healing and regeneration. The review also discusses the merits and demerits of using TA in developing hydrogels either through direct incorporation in the hydrogel formulation or indirectly via immersing the final product in a TA solution. In general, TA is a natural bioactive molecule with diverse potential for engineering biomedical hydrogels.

Graphical abstract: Tannic acid: a versatile polyphenol for design of biomedical hydrogels

Article information

Article type
Review Article
Submitted
18 5 2022
Accepted
09 7 2022
First published
13 7 2022

J. Mater. Chem. B, 2022,10, 5873-5912

Tannic acid: a versatile polyphenol for design of biomedical hydrogels

H. Jafari, P. Ghaffari-Bohlouli, S. V. Niknezhad, A. Abedi, Z. Izadifar, R. Mohammadinejad, R. S. Varma and A. Shavandi, J. Mater. Chem. B, 2022, 10, 5873 DOI: 10.1039/D2TB01056A

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