Issue 8, 2022

Ionic liquid exfoliated Ti3C2Tx MXene nanosheets for photoacoustic imaging and synergistic photothermal/chemotherapy of cancer

Abstract

Ti3C2Tx MXene is a new type of two-dimensional material with good biocompatibility and a good photothermal effect, and shows great potential in cancer treatment. In this study, few-layer ionic liquid (IL)-Ti3C2Tx MXene nanosheets were synthesized using IL stripping technology, which have high chemical stability, and allow photoacoustic imaging and synergistic photothermal/chemotherapy of cancer. Under 808 nm laser irradiation, the nanosheets have strong absorption in the near-infrared region, and high photothermal conversion efficiency (∼63.91%). Using DOX as a model drug, the IL-Ti3C2Tx MXene@DOX nanosheets exhibited high drug loading capacity and pH-/photosensitivity, which will further promote the drug release of the nanosheets in an acidic tumor microenvironment and under 808 nm laser irradiation. In vitro and in vivo experiments showed that IL-Ti3C2Tx MXene@DOX has good biological safety, allows remarkable photoacoustic imaging, and can effectively kill cancer cells with synergistic photothermal/chemotherapy. Therefore, IL-Ti3C2Tx MXene nanosheets are expected to provide powerful and useful two-dimensional nanoplatforms for various biomedical applications.

Graphical abstract: Ionic liquid exfoliated Ti3C2Tx MXene nanosheets for photoacoustic imaging and synergistic photothermal/chemotherapy of cancer

Supplementary files

Article information

Article type
Paper
Submitted
04 9 2021
Accepted
17 12 2021
First published
08 1 2022

J. Mater. Chem. B, 2022,10, 1226-1235

Ionic liquid exfoliated Ti3C2Tx MXene nanosheets for photoacoustic imaging and synergistic photothermal/chemotherapy of cancer

B. Lu, S. Hu, D. Wu, C. Wu, Z. Zhu, L. Hu and J. Zhang, J. Mater. Chem. B, 2022, 10, 1226 DOI: 10.1039/D1TB01938D

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