Issue 42, 2022

Light-driven biocatalytic oxidation

Abstract

Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired approaches for sustainable chemical synthesis. Oxidative enzymes (e.g., monooxygenases, peroxygenases, oxidases, or dehydrogenases) catalyze a variety of enantioselective oxyfunctionalization and dehydrogenation reactions under mild conditions. To sustain the catalytic cycles of these enzymes, constant supply with or withdrawal of reducing equivalents (electrons) is required. Being redox by nature, photocatalysis appears a ‘natural choice’ to accomplish the electron-relay role, and many photoenzymatic oxidation reactions have been developed in the past years. In this contribution, we critically summarize the current developments in photoredoxbiocatalysis, highlight some promising concepts but also discuss the current limitations.

Graphical abstract: Light-driven biocatalytic oxidation

Article information

Article type
Perspective
Submitted
22 6 2022
Accepted
30 9 2022
First published
30 9 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 12260-12279

Light-driven biocatalytic oxidation

C. Yun, J. Kim, F. Hollmann and C. B. Park, Chem. Sci., 2022, 13, 12260 DOI: 10.1039/D2SC03483B

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