Issue 29, 2022

Radical transformations for allene synthesis

Abstract

Allenes are valuable organic molecules that feature unique physical and chemical properties. They are not only often found in natural products, but also act as versatile building blocks for the access of complex molecular targets, such as natural products, pharmaceuticals, and functional materials. Therefore, many remarkable and elegant methodologies have been established for the synthesis of allenes. Recently, more and more methods for radical synthesis of allenes have been developed, clearly emphasizing the associated great synthetic values. In this perspective, we will discuss recent important advances in the synthesis of allenes via radical intermediates by categorizing them into different types of substrates as well as distinct catalytic systems. The mechanistic studies and synthetic challenges will be highlighted.

Graphical abstract: Radical transformations for allene synthesis

Article information

Article type
Perspective
Submitted
09 5 2022
Accepted
28 6 2022
First published
29 6 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 8491-8506

Radical transformations for allene synthesis

Y. Li and H. Bao, Chem. Sci., 2022, 13, 8491 DOI: 10.1039/D2SC02573F

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