Issue 20, 2022

A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics

Abstract

The exploration of cellular organelle-specific anchoring photosensitizers with both prominent fluorescence imaging behavior and extraordinary reactive oxygen species (ROS) production capability is highly in demand but remains a severe challenge for effective cancer theranostics involving photodynamic therapy (PDT). In this contribution, we developed a cell membrane-targeting and NIR-emission photosensitizer having an aggregation-induced emission (AIE) tendency. The AIE photosensitizer, namely TBMPEI, is capable of lighting up and ablating cancer cells by means of a necroptosis procedure enabling cell membrane rupture and DNA degradation upon light irradiation, endowing TBMPEI with impressive performance for both in vitro and in vivo fluorescence imaging-guided PDT.

Graphical abstract: A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics

Supplementary files

Article information

Article type
Edge Article
Submitted
03 3 2022
Accepted
12 4 2022
First published
19 4 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 5929-5937

A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics

N. Niu, Y. Yu, Z. Zhang, M. Kang, L. Wang, Z. Zhao, D. Wang and B. Z. Tang, Chem. Sci., 2022, 13, 5929 DOI: 10.1039/D2SC01260J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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