Issue 48, 2022

Nanotechnology strategies for hepatocellular carcinoma diagnosis and treatment

Abstract

Hepatocellular carcinoma (HCC) is a common malignancy threatening human health, and existing diagnostic and therapeutic techniques are facing great challenges. In the last decade or so, nanotechnology has been developed and improved for tumor diagnosis and treatment. For example, nano-intravenous injections have been approved for malignant perivascular epithelioid cell tumors. This article provides a comprehensive review of the applications of nanotechnology in HCC in recent years: (I) in radiological imaging, magnetic resonance imaging (MRI), fluorescence imaging (FMI) and multimodality imaging. (II) For diagnostic applications in HCC serum markers. (III) As embolic agents in transarterial chemoembolization (TACE) or directly as therapeutic drugs. (IV) For application in photothermal therapy and photodynamic therapy. (V) As carriers of chemotherapeutic drugs, targeted drugs, and natural plant drugs. (VI) For application in gene and immunotherapy. Compared with the traditional methods for diagnosis and treatment of HCC, nanoparticles have high sensitivity, reduce drug toxicity and have a long duration of action, and can also be combined with photothermal and photodynamic multimodal combination therapy. These summaries provide insights for the further development of nanotechnology applications in HCC.

Graphical abstract: Nanotechnology strategies for hepatocellular carcinoma diagnosis and treatment

Article information

Article type
Review Article
Submitted
16 8 2022
Accepted
20 10 2022
First published
31 10 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 31068-31082

Nanotechnology strategies for hepatocellular carcinoma diagnosis and treatment

W. Jia, Y. Han, X. Mao, W. Xu and Y. Zhang, RSC Adv., 2022, 12, 31068 DOI: 10.1039/D2RA05127C

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