Issue 18, 2022

Highly selective electrophilic B(9)-amination of o-carborane driven by HOTf and HFIP

Abstract

Despite the great importance of nitrogen-containing carboranes in organic and pharmaceutical syntheses, current methods to generate them are very limited and usually rely on the use of expensive transition metals. Herein, an efficient B(9) electrophilic amination of o-carboranes with azodicarboxylates, promoted by a Brønsted acid and HFIP, has been developed. The reaction proceeded smoothly under metal-free conditions and could be easily scaled up, giving B(9)-aminated o-carboranes in moderate to good yields and excellent selectivity under air.

Graphical abstract: Highly selective electrophilic B(9)-amination of o-carborane driven by HOTf and HFIP

Supplementary files

Article information

Article type
Research Article
Submitted
07 5 2022
Accepted
31 7 2022
First published
03 8 2022

Org. Chem. Front., 2022,9, 4975-4980

Highly selective electrophilic B(9)-amination of o-carborane driven by HOTf and HFIP

Y. Wang, Y. Gao, W. Guo, Q. Zhao, Y. Ma and X. Chen, Org. Chem. Front., 2022, 9, 4975 DOI: 10.1039/D2QO00732K

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