Issue 31, 2022

Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

Abstract

Described is a total synthesis of racemic mersicarpine from diethyl 4-oxopimelate. The synthetic route takes advantage of a 2-indolyl radical cyclization to construct the pyrido[1,2-a]indole scaffold bearing the all-carbon quaternary stereocenter.

Graphical abstract: Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

  • This article is part of the themed collection: New Talent

Supplementary files

Article information

Article type
Communication
Submitted
02 4 2022
Accepted
19 4 2022
First published
21 4 2022

Org. Biomol. Chem., 2022,20, 6193-6195

Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

W. Peng, Y. Jhang, C. Chang, P. Peng, W. Zhao and Y. Wu, Org. Biomol. Chem., 2022, 20, 6193 DOI: 10.1039/D2OB00620K

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