Issue 30, 2022

The use of bromopyridazinedione derivatives in chemical biology

Abstract

Tools that facilitate the chemical modification of peptides and proteins are gaining an increasing amount of interest across many avenues of chemical biology as they enable a plethora of therapeutic, imaging and diagnostic applications. Cysteine residues and disulfide bonds have been highlighted as appealing targets for modification due to the highly homogenous nature of the products that can be formed through their site-selective modification. Amongst the reagents available for the site-selective modification of cysteine(s)/disulfide(s), pyridazinediones (PDs) have played a particularly important and enabling role. In this review, we outline the unique chemical features that make PDs especially well-suited to cysteine/disulfide modification on a wide variety of proteins and peptides, as well as provide context as to the problems solved (and applications enabled) by this technology.

Graphical abstract: The use of bromopyridazinedione derivatives in chemical biology

  • This article is part of the themed collection: New Talent

Article information

Article type
Review Article
Submitted
14 2 2022
Accepted
28 3 2022
First published
30 3 2022
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2022,20, 5879-5890

The use of bromopyridazinedione derivatives in chemical biology

C. Bahou and V. Chudasama, Org. Biomol. Chem., 2022, 20, 5879 DOI: 10.1039/D2OB00310D

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