Issue 24, 2022

Factors influencing stoichiometry and stability of polyoxometalate – peptide complexes

Abstract

In the pursuit of understanding the factors guiding interactions between polyoxometalates (POMs) and biomolecules, several complexes between Keggin phosphomolybdate and diglycine have been produced at different acidity and salinity conditions, leading to difference in stoichiometry and in crystal structure. Principal factors determining how the POM and dipeptide interact appear to be pH, ionic strength of the medium, and the molar ratio of POM to peptide. An important effect turned out to be even the structure-directing role of the sodium cations coordinating carbonyl functions of the peptide bond. Given the interest in applying POMs in biological systems, these factors are highly relevant to consider. In the view of recent interest in using POMs as nano catalysts in peptide hydrolysis also the potential Keggin POM transformation in phosphate buffered saline medium was investigated leading to insight that nanoparticles of zirconium phosphate (ZrP) can be actual catalysts for breakdown of the peptide bond.

Graphical abstract: Factors influencing stoichiometry and stability of polyoxometalate – peptide complexes

Supplementary files

Article information

Article type
Paper
Submitted
06 3 2022
Accepted
07 6 2022
First published
07 6 2022
This article is Open Access
Creative Commons BY license

Dalton Trans., 2022,51, 9511-9521

Factors influencing stoichiometry and stability of polyoxometalate – peptide complexes

B. H. Greijer, G. Nestor, J. E. Eriksson, G. A. Seisenbaeva and V. G. Kessler, Dalton Trans., 2022, 51, 9511 DOI: 10.1039/D2DT00717G

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