Issue 90, 2022

Catch-enrich-release approach for amine-containing natural products

Abstract

Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.

Graphical abstract: Catch-enrich-release approach for amine-containing natural products

Supplementary files

Article information

Article type
Communication
Submitted
05 9 2022
Accepted
14 10 2022
First published
17 10 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 12560-12563

Catch-enrich-release approach for amine-containing natural products

M. J. Müller, A. Dorst, C. Paulus, I. Khan and S. Sieber, Chem. Commun., 2022, 58, 12560 DOI: 10.1039/D2CC04905H

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